Read e-book online Acute Exposure Guideline Levels for Selected Airborne PDF

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

ISBN-10: 030908511X

ISBN-13: 9780309085113

ISBN-10: 0309567734

ISBN-13: 9780309567732

Record from the Subcommittee on Acute publicity instruction degrees and the Committee on Toxicology from the Board on Environmental reports and Toxicology. quantity 2. Softcover.

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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2

Example text

Manufacture of phosgene is approximately 1 million tons per year (y) in the United States, and more than 10,000 workers are involved in its manufacture and use (Currie et al. 1987a). Manufacture of phosgene in the United States is almost entirely captive (more than 99% is used in the manufacture of other chemicals within a plant boundary). S. merchant market. Over 80% of the phosgene used in the United States is involved in the manufacture of polyisocyanates in the polyurethane industry. The polycarbonate industry accounts for approximately 10% of phosgene used, and the remaining 10% is used in the production of aliphatic diisocyanates, monoisocyanates, chloroformates, agrochemicals, and intermediates for dyestuffs and pharmaceuticals.

Phosgene is manufactured from a reaction of carbon monoxide and chlorine gas in the presence of activated charcoal. The production of dyestuffs, isocyanates, carbonic acid esters (polycarbonates), acid chlorides, insecticides, and pharmaceutical chemicals requires phosgene. Manufacture of phosgene is approximately 1 million tons per year (y) in the United States, and more than 10,000 workers are involved in its manufacture and use. Manufacture of phosgene in the United States is 1This document was prepared by AEGL Development Team member Cheryl Bast of Oak Ridge National Laboratory and Bill Bress (Chemical Manager) of the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances (NAC).

There were no differences in pulmonary function or deaths attributable to respiratory disease between the exposed and control populations. 3. Developmental and Reproductive Toxicity Developmental and reproductive studies regarding acute human exposure to phosgene were not available. 4. Genotoxicity Genotoxic studies regarding acute human exposure to phosgene were not available. 5. Carcinogenicity Polednak (1980) and Polednak and Hollis (1985) examined a cohort of chemical workers exposed to phosgene at chronic low levels as well as daily exposures above 1 ppm.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels


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