Advances in Heterocyclic Chemistry by Alan R. Katritzky PDF

By Alan R. Katritzky

ISBN-10: 0120206064

ISBN-13: 9780120206063

(from preface)The influence of substituents on benzenoid reactivity has been probably the most largely investigated branches of chemistry. The scattered facts on pyridine substitution at the moment are assembled in a overview through R. A. Abramovitch and J. G. Saha that's as invaluable for exhibiting what is still performed as for what has been accomplished. R. E. Lyle and P. S. Anderson survey reactions of nitrogen heterocycles with complicated hydrides, and the heterocyclic chemistry of nitriles and nitrilium salts is roofed via P. Johnson and R. Madronero.Each of the rest 3 chapters offers with a gaggle of compounds: cyclic en amines (K. Blaha and O. Cervinka), pyrazoles (A. N. Kost and that i. I. Grandberg), and physicochemical points of purines (J. H. Lister).Suggestions are welcome for contributions to additional volumes; they need to be within the kind of a brief synopsis.We thank the Editorial Board, the publishers, and the authors for his or her cooperation.

Show description

Read Online or Download Advances in Heterocyclic Chemistry PDF

Best organic books

Get Renal Transport of Organic Substances PDF

This e-book is a set of stories at the renal delivery of natural ingredients. the 1st chapters care for common facets of the subject. the subsequent articles deal with the current wisdom at the renal trans­ port of particular compounds or sessions of natural elements, while the fmal bankruptcy on comparative body structure bargains with the renal trans­ port of natural ingredients in non-mammalian vertebrates.

Extra resources for Advances in Heterocyclic Chemistry

Example text

8 3 E. N. Shaw, J . A m . Chern. SOC. 80,3899 (1958). 84 R. H. Lindsay, W. H. Paik, and P. P. Cohen, Biochim. Biophya. Acta 58,585 81 82 (1962). A. Albert and D. J. Brown, J . Chem. SOC. 1954, 2060. 86 J. A. Montgomery and C. Temple, J . Am. Chem. SOC. 79, 5238 (1957). 85 Sec. 1 23 PHYSICOCHEMICAL ASPECTS OF PURINES further attack. The presence of even traces of methanol in this reaction, if carried out a t room temperature, leads to preferential formation of 6 - m e t h o x y p ~ i n e . ~ ' The instability of simple purine ribosides toward alkaliAs-89 can be related to the fairly strong electron-withdrawing power of the ribose moiety, which directs the nucleophile to the 8-carbon.

82, 3773 (1960). Shapiro, J . Am. Chem. SOC. 86, 2948 (1964). 119 32 J. H. LISTER [Sec. 111. electron-deficient character of the %carbon atom, this reaction is proposed to occur via a nucleophilic substitution by nitrite ion of the diazonium group. 121a Another route (69-+68) producing 8-nitropurines was initially considered to have given 8-nitrosopurines,l l 9but these were shown later to be mixtures of 8-nitropurines and starting material121; here an 8-thione group (69) undergoes electrophilic substitution by a nitronium ion.

Gulland and L. F. Storey, J . Chem. Soc. 1938, 692. 79 H. C. Koppel and R. K. Robins, J . Am. Chem. SOC. 80, 2751 (1958). 80 R. M. Cresswell and G. B. Brown, J . Org. Chem. 28, 2560 (1963). 77 78 J. H. LISTER 22 [Sec. 111. H (35) 4. Nueleophilic Substitution Leading to Degradation or Rearrangement a. Degradation. ~~ imidazole derivatives. s4 Stability toward alkali is a feature of 0x0 derivatives and purines containing electron-releasing groups, while N-alkylation, which may prohibit anion formation, has the opposite effect.

Download PDF sample

Advances in Heterocyclic Chemistry by Alan R. Katritzky

by Edward

Rated 4.11 of 5 – based on 36 votes

Related posts